Annuaire
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Personnel de recherche

M. William Raoul

Chargé de recherche Inserm

Coordonnées

10 Boulevard Tonnellé 37032 TOURS CEDEX 1

Tonnellé bâtiment H étage 5 bureau 503

Tél
0247366267
Mail
william.raoul@univ-tours.fr
Site internet
http://cvscience.aviesan.fr/cv/522/william-raoul

Discipline(s)

Sciences biologiques, fondamentales et cliniques

Thèmes de recherche

cancer, angiogenèse, inflammation, canaux ioniques, anticorps monoclonaux thérapeutiques, pharmacologie, pharmacocinétique, recherche translationnelle, études ancillaires, biomarqueurs

Activités / CV

2017 Habilitation à Diriger des Recherches, Université François Rabelais de Tours

2005 Doctorat de Sciences de la Vie et de la Santé, Toxicologie, Université Paris XII-Créteil

2001 Diplôme d'études approfondies, Toxicologie, Université Paris V-Descartes

2000 Maîtrise de Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil

Informations complémentaires

Publications majeures
1. Ibrahim S, Dakik H, Vandier C, Chautard R, Paintaud G, Mazurier F, Lecomte T, Guéguinou M, Raoul W. Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. Cancers (Basel). 2019 Apr 19;11(4). pii: E561. doi: 10.3390/cancers11040561.

2. Ternant D, Azzopardi N, Raoul W, Bejan-Angoulvant T, Paintaud G. Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans. Clin Pharmacokinet. 2019 Feb;58(2):169-187. doi: 10.1007/s40262-018-0680-3. Review.

3. Ibrahim S, Girault A, Ohresser M, Lereclus E, Paintaud G, Lecomte T, Raoul W. Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer? Clin Colorectal Cancer. 2018 Mar;17(1):e109-e113. doi: 10.1016/j.clcc.2017.10.003. Epub 2017 Oct 28. Review.

4. Lereclus E, Tout M, Girault A, Baroukh N, Caulet M, Borg C, Bouché O, Ternant D, Paintaud G, Lecomte T, Raoul W. A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen. BMC Cancer. 2017 Mar 27;17(1):220. doi: 10.1186/s12885-017-3210-z.

5. Calippe B, Augustin S, Beguier F, Charles-Messance H, Poupel L, Conart JB, Hu SJ, Lavalette S, Fauvet A, Rayes J, Levy O, Raoul W, Fitting C, Denèfle T, Pickering MC, Harris C, Jorieux S, Sullivan PM, Sahel JA, Karoyan P, Sapieha P, Guillonneau X, Gautier EL, Sennlaub F. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Immunity. 2017 Feb 21;46(2):261-272. doi: 10.1016/j.immuni.2017.01.006.

6. Camelo S, Calippe B, Lavalette S, Dominguez E, Hur J, Devevre E, Guillonneau X, Raoul W, Sennlaub F. Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. Mol Vis. 2015 Sep 2;21:1051-9. eCollection 2015.

7. Selbonne S, Francois D, Raoul W, Boulaftali Y, Sennlaub F, Jandrot-Perrus M, Bouton MC, Arocas V. Protease nexin-1 regulates retinal vascular development. Cell Mol Life Sci. 2015 Oct;72(20):3999-4011. doi: 10.1007/s00018-015-1972-5. Epub 2015 Jun 25.

8. Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, Dominguez E, Camelo S, Levy O, Guyon E, Saederup N, Charo IF, Rooijen NV, Nandrot E, Bourges JL, Behar-Cohen F, Sahel JA, Guillonneau X, Raoul W, Combadiere C. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.

9. Lavalette S, Raoul W, Houssier M, Camelo S, Levy O, Calippe B, Jonet L, Behar-Cohen F, Chemtob S, Guillonneau X, Combadière C, Sennlaub F. Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. Am J Pathol. 2011 May;178(5):2416-23. doi: 10.1016/j.ajpath.2011.01.013.

10. Raoul W, Auvynet C, Camelo S, Guillonneau X, Feumi C, Combadière C, Sennlaub F. CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration. J Neuroinflammation. 2010 Dec 2;7:87. doi: 10.1186/1742-2094-7-87. Review.

11. Houssier M, Raoul W, Lavalette S, Keller N, Guillonneau X, Baragatti B, Jonet L, Jeanny JC, Behar-Cohen F, Coceani F, Scherman D, Lachapelle P, Ong H, Chemtob S, Sennlaub F. CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. PLoS Med. 2008 Feb;5(2):e39. doi: 10.1371/journal.pmed.0050039.

12. Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, Lavalette S, Houssier M, Jonet L, Picard E, Debré P, Sirinyan M, Deterre P, Ferroukhi T, Cohen SY, Chauvaud D, Jeanny JC, Chemtob S, Behar-Cohen F, Sennlaub F. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest. 2007 Oct;117(10):2920-8.

13. Raoul W, Wagner-Ballon O, Saber G, Hulin A, Marcos E, Giraudier S, Vainchenker W, Adnot S, Eddahibi S, Maitre B. Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice. Respir Res. 2007 Jan 30;8:8.

14. Guignabert C, Raffestin B, Benferhat R, Raoul W, Zadigue P, Rideau D, Hamon M, Adnot S, Eddahibi S. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Circulation. 2005 May 31;111(21):2812-9.

15. Raoul W, Chailley-Heu B, Barlier-Mur AM, Delacourt C, Maître B, Bourbon JR. Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1293-301. Epub 2004 Jan 23.