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microbial supply chain for production of the anti-cancer drug vinblastine from Jie Zhang Lea G. Hansen Olga Gudich Catharanthus roseus which is then followed by simple in vitro chemical coupling and reduction to form vinblastine catharanthine using a highly engineered yeast and in vitro chemical coupling to vinblastine. The study pyrophosphate and tryptophan to catharanthine and vindoline. In total 56 genetic edits were performed including expression Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr Dr Emily Stander France 3 Région CvdL Engineered yeast brews precursors of anticancer drug vinblastine collaborators. Dr Vincent Courdavault , assistant professor in our lab and Emily A. Stander, former post-doctoral researcher are co-authors of this paper published in Nature. chain for production of the anti-cancer drug vinblastine published in NATURE!

students coming in semester 1 or for the whole academic year By 15 November for students coming in semester candidature . Click on this. The form comes up. Fill it in on the screen.* When you have finished click on valider send it with 2 photos to Mr SOREAU see address below in the accommodation part . *Some more help Composante 1/ Online registration

machine augmentation and more recently rejection. In this work we present a framework that unifies the with respect to the domain of the adversary. This in turn allows the natural concept of duality for mathematical and we propose a primal-dual algorithm for the online scheduling problem of minimizing the total weighted inspired by this greedy algorithm we present an online heuristic for non-preemptive scheduling sequential Online non-preemptive scheduling with resource augmentation

missing enzymes achieving key steps in the paclitaxel biosynthetic pathway in yew and reconstituted the production https doi.org 10.1038 s41422-024-00950-3 Abstract In a recently published Science article Jiang et al production of the main precursor baccatin III in a heterologous host. This advance provides unprecedented biotechnological production of this prominent anticancer drug. Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr Metabolic engineering of the paclitaxel anticancer drug

to discuss about our project dedicated to marine drug products to provide innovative solutions for supplying Marine drug metabolism consortium - 1st meeting

Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr Metabolic engineering of the paclitaxel anticancer drug

Artificial intelligence for natural product drug discovery. Nat Rev Drug Discov. 2023 Nov 22 11 895-916. doi natural products unearthing new potential for drug discovery. In parallel artificial intelligence approaches learning have led to exciting developments in the computational drug design field facilitating biological activity Artificial intelligence for natural product drug discovery Mullowney MW Duncan KR Elsayed SS Garg N van 10.1038 s41573-023-00774-7. Abstract Developments in computational omics technologies have provided new In this review article published in Nature Reviews drug discovery, Dr Mehdi Beniddir from the ANR project between these developments to effectively identify drug candidates from the plethora of molecules produced Artificial intelligence for natural product drug discovery

new chassis for drug production by Vincent Courdavault1* and Nicolas Papon2* Trends in Biotechnology 2022 discoideum could be also engineered in favor of the production of plant drug precursors. Engineered bacteria and yeasts have progressively emerged in the past decade as convenient cell factories for Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr as a new chassis for drug production : our new spotlight published in Trends in Biotechnology Social amoebae as a new chassis for drug production

Chromosome-scale genomes throw light on plant drug biosynthesis by Emily Amor Stander1 4 Thomas Dugé Bernonville2'4 Nicolas Papon3 and Vincent Courdavault1* Trends in Pharmacological Sciences 2022 https doi.org 10.1016 technologies also facilitate the identification of plant drug biosynthetic genes and would likely accelerate the Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr metabolic pathways. A story related in our new paper published in Trends in Pharmacological Sciences! Chromosome-scale genomes throw light on plant drug biosynthesis

the potential benefit of using offline and online methods in tandem as a hybrid ADP procedure making possible stochastic service requests an important problem in city-based logistics. We contribute to the routing enhancing the anticipation of the VFA policy resulting in spatial-temporal rollout policies. Our combination Offline-Online Approximate Dynamic Programming for Dynamic Vehicle Routing with Stochastic Requests