M. William Raoul

Tél

0247366267

Mail

william.raoul@univ-tours.fr

Site internet

https://cv.hal.science/william-raoul

2017: Habilitation à Diriger des Recherches, Oncologie digestive, Université François-Rabelais de Tours

2005: Doctorat de Sciences de la Vie et de la Santé, Toxicologie pulmonaire, Université Paris XII-Créteil

2001: Diplôme d'études approfondies, Toxicologie générale, Université Paris V-Descartes

2000: Maîtrise, Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil

Publications depuis 2020

* Monbet V, Raoul W, Emond P, Gueguinou M, Lefevre A, Dolly A, Anon B, Dorval E, Chautard R, Cottet V, Lepage C, Manfredi S, Blasco H, Lecomte T, Sire O. Integrative analysis of circulating biomarkers of colorectal cancer combining mid-infrared spectroscopy and targeted metabolomics. Spectrochim Acta A Mol Biomol Spectrosc. 2026.

* Corset L, Picou F, Beilstein F, Ibrahim S, Chautard R, Marouillat S, Hérault O, Lecomte T, Raoul W. Data on microRNA transcriptomic signatures, predicted gene targets and pathway analysis in response to cetuximab or panitumumab in colorectal cancer cells. Data Brief. 2026.

* Victoir B, Pertegaz O, Ducrocq E, Polomski M, Guéguinou M, Raoul W, Croix C, Prié G. Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents. Results in Chemistry. 2025.

* Robert A, Crottès D, Bourgeais J, Gueguen N, Chevrollier A, Dumas JF, Servais S, Domingo I, Chadet S, Sobilo J, Hérault O, Lecomte T, Vandier C, Raoul W, Guéguinou M. MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development. PLoS Biol. 2024.

* Chautard R, Caulet M, Bouché O, Borg C, Manfredi S, Capitain O, Spano JP, Raoul W, Guéguinou M, Herault O, Ferru A, Pobel C, Sire O, Lecomte T. Evaluation of serum mid-infrared spectroscopy as new prognostic marker for first-line bevacizumab-based chemotherapy in metastatic colorectal cancer. Dig Liver Dis. 2024.

* Vilímová I, David S, Vigouroux C, Raoul W, Corset L, Misericordia Y, Chourpa I, Hervé-Aubert K. Fe3O4-Based Magnetic Nanoprobes for miRNA-484 Capture in Human Serum: Implications for Colorectal Cancer Screening. ACS Appl. Nano Mater. 2024.

* Roy M, Alix C, Burlaud-Gaillard J, Fouan D, Raoul W, Bouakaz A, Blanchard E, Lecomte T, Viaud-Massuard MC, Sasaki N, Serrière S, Escoffre JM. Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model. Mol Pharm. 2024.

* Romito O, Guéguinou M, Raoul W, Champion O, Robert A, Trebak M, Goupille C, Potier-Cartereau M. Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer. Cell Calcium. 2022.

* Guéguinou M, Ibrahim S, Bourgeais J, Robert A, Pathak T, Zhang X, Crottès D, Dupuy J, Ternant D, Monbet V, Guibon R, Flores-Romero H, Lefèvre A, Lerondel S, Le Pape A, Dumas JF, Frank PG, Girault A, Chautard R, Guéraud F, García-Sáez AJ, Ouaissi M, Emond P, Sire O, Hérault O, Fromont-Hankard G, Vandier C, Tougeron D, Trebak M, Raoul W, Lecomte T. Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer. Cell Mol Life Sci. 2022.
* Chautard R, Corset L, Ibrahim S, Desvignes C, Paintaud G, Baroukh N, Guéguinou M, Lecomte T, Raoul W. Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells. Biomark Med. 2021. 

* Desvignes C, Ternant D, Lecomte T, Lièvre A, Ohresser M, Chautard R, Raoul W, Paintaud G. A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations. Bioanalysis. 2021.

* Ibrahim S, Chaigne J, Dakik H, Fourbon Y, Corset L, Lecomte T, Raoul W, Guéguinou M. SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. Cell Calcium. 2021.

* Oyallon B, Brachet-Botineau M, Logé C, Souab M, Robert T, Bach S, Ibrahim S, Raoul W, Berthelot P, Gouilleux F, Viaud-Massuard MC, Denevault-Sabourin C. New quinoxaline derivatives as dual Pim-1/Pim-2 inhibitors: design, synthesis and biological evaluation. Molecules. 2021.

* Potier-Cartereau M, Raoul W, Weber G, Mahéo K, Rapetti-Mauss R, Gueguinou M, Buscaglia P, Goupille C, Le Goux N, Abdoul-Azize S, Lecomte T, Fromont G, Chantome A, Mignen O, Soriani O & Vandier C. Potassium and calcium channel complexes as novel targets for research in cancer. Rev Physiol Biochem Pharmacol. 2020.

* Dolly A, Dumas JF, Lecomte T, Bouché O, Borg C, Terrebonne E, Douillard JY, Chautard R, Raoul W, Ternant D, Leger J, Bleuzen A, Servais S, Baracos VE. Concurrent losses of skeletal muscle mass, adipose tissue and bone mineral density during bevacizumab / cytotoxic chemotherapy treatment for metastatic colorectal cancer. Clinical nutrition. 2020.