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organization in planta. Besides allowing a better understanding of the MIA biosynthetic flux in the whole compounds now find application for human health. In this respect the monoterpene indole alkaloids MIAs been a challenge since the low-yield accumulation in planta. This mainly results from the complex architecture Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr more than a plant, an alkaloid factory! A review in Current Opinion Plant Biology.

Triterpenes are C30 organic compounds abundantly found in all living organisms. Although previously believed Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr discovered a new pathway for triterpene biosynthesis in which bifunctional class I terpene synthases from

Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

for the biotechnological production of plant drugs. In a new report Li et al. used a single-cell multi-omics architecture and regulation of anticancer alkaloid routes in Madagascar periwinkle. Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr Our new spotlight published in Trends in Plant Science, on a report by Li et al on single-cell multi-omics and regulation of anticancer alkaloid biosynthesis in medicinal plants.

Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

conservation of enzymes involved in the final stages of MIA biosynthesis in the distinct MIA-producing plant emergence and loss of cardenolide and MIA biosynthesis in Apocynaceae we sequenced and assembled the P. lamerei 48 of the genome emerge as potential key players in shaping genomic architecture and influencing specialized biosynthetic genes such as strictosidine synthase in P. lamerei and non-Rauvolfioideae species hints at also underscores the role of transposable elements in this intricate process. Moreover we shed light on Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

important PNPs in various heterologous hosts. Here we spotlight unprecedented advancements in the field of 2020. We also discuss how the knowledge accumulated in recent years could pave the way for a broader manufacturing Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

sodium-induced changes in thraustochytrid metabolism leading to a twofold increase in squalene accumulation squalene are valuable compounds for cosmetic and drug industries the supply of which is often limited decades but remain challenging due to low yields. In a recent study Zhang and coworkers A. Zhang K. Mernitz of marine thraustochytrid metabolic thermodynamics in effective terpene engineering. Through comparative above all displays thermodynamics as a valuable tool in metabolic engineering. Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr

immense potential in the medicine and food industry. The recent advancements in omics applied in deciphering high-quality genome releases and the wealth of data in metabolomics and transcriptomics. While harnessing whether integrated or standalone has proven successful in unveiling plant natural product PNP biosynthetic pathways the democratization of machine learning in biology opens exciting new opportunities for enhancing This review highlights the recent breakthroughs in disrupting plant-specialized biosynthetic pathways Dr Vincent Courdavault email vincent.courdavault@univ-tours.fr