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Enseignant hospitalo-universitaire

M. Denis Mulleman

- Member of the Innovation and Cell Targeting Group (GICC), Team PATCH: “Pharmacology of Therapeutic Antibodies in Human”, Head : Prof. Gilles Paintaud - Coordinator of the Consortium «Monitoring of monoclonal Antibodies Group in Europe» (MAGE) for inflammatory diseases - Representative in the ABIRISK consortium ( dedicated to immunogenicity to biopharmaceutical March 2012-March 2018. - Co-leader of the key question N°3 of the Laboratory of Excellence MabImprove (“How can antibodies efficacy can be increased using combination)


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Thèmes de recherche

Concentration-response relationship of monoclonal antibodies in inflammatory rheumatic diseases

Activités / CV

Clinical studies:
  1. Positron Emission Tomography in Rheumatoid Arthritis With Adalimumab (PETRA) NCT00497614 (Principal Investigator)
  2. Pharmaco Kinetic Variability of Infliximab in Rheumatoid Arthritis (FAKIR) NCT00840957 (Principal Investigator)
  3. Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA) NCT01382160 (Principal Investigator)
  4. Combinaison of Methotrexate to Adalimumab to Reduce Immunization in ankylosing Spondylitis (CoMARIS) NCT01895764 (Co-Investigator)
  5. Relationship between T LYmphocytes depletion and clinical response to RITUXimab in rheumatoid arthritis (LYRITUX) NCT02304354 (Co-Investigator)

Key words: biopharmaceuticals, monoclonal antibodies, concentration-response relationship, modelling, therapeutic drug monitoring, immunogenicity, quantitative systems pharmacology, inflammatory rheumatic diseases

Informations complémentaires

MabImprove Laboratory of Excellence
Monitoring of monoclonal Antibodies Group in Europe (MAGE)
ABIRISK consortium
Biopharmaceuticals Pharmacokinetic and Immunogenicity assessment (BIOPIA)